Bile acids go nuclear!
نویسندگان
چکیده
منابع مشابه
Bile acids are physiological ligands for a nuclear receptor.
Bile acids are essential for the solubilization and transport of dietary lipids and are the major products of cholesterol catabolism. Results presented here show that bile acids are physiological ligands for the farnesoid X receptor (FXR), an orphan nuclear receptor. When bound to bile acids, FXR repressed transcription of the gene encoding cholesterol 7 alpha-hydroxylase, which is the rate-lim...
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Transcription regulation by bile acids is far more complicated than it appeared at first when several groups began their investigations in the early '90. It has become clear now that bile acids regulate the transcription of genes involved in bile acid synthesis, transport and other metabolic pathways via multiple mechanisms that involve transcription factors, nuclear receptors, coregulators, ch...
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Airaudo ChB, Gayte-Sorbier A, Aujoulat P and Mercier V (1988) Thin-layer chromatography of amine antioxidants and antiozonants used in elastomers. Journal of Chromatography 437: 59}82. FateH r Z, Tasi G, Szabady B and Nyiredy Sz (1998) IdentiRcation of amphetamine derivatives by uni-dimensional multiple development and two-dimensional HPTLC combined with postchromatographic derivatization. Jour...
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Bile acids are physiological detergents that facilitate excretion, absorption, and transport of fats and sterols in the intestine and liver. Recent studies reveal that bile acids also are signaling molecules that activate several nuclear receptors and regulate many physiological pathways and processes to maintain bile acid and cholesterol homeostasis. Mutations of the principal regulatory genes...
متن کاملNuclear receptors sense bile acid metabolism: A hormonal action of bile acids
Bile acids, the major catabolic products of cholesterol, are essential components in bile and act as a detergent for the intestinal ingestion of lipidsoluble nutrients. In addition to these classical roles, bile acids have more recently been identified as signaling molecules that activate nuclear receptors, ligand-inducible transcription factors. Nuclear receptors, such as liver X receptor α (L...
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ژورنال
عنوان ژورنال: Hepatology
سال: 1999
ISSN: 0270-9139,1527-3350
DOI: 10.1002/hep.510300439